Abstract

Abstract

This study explores how the natural components of Aloes Compound Vet. Granules an age-old Ayurvedic remedy interact with important reproductive receptors in chickens. Using molecular docking techniques, we looked at how some of these key constituents bind to receptors like Estrogen receptor alpha (ESR1), Progesterone receptor (PGR), Thyroid hormone receptor beta (THRβ). These receptors play vital roles in follicle development, ovulation, hormone balance and early reproductive maturation. To give context, we included known ligands like estradiol, progesterone and liothyronine as controls. This way, we could compare how well the natural compounds performed. Certain compounds Rutin, Rubiadin and Friedelin stood out because they showed strong binding affinities, often mimicking how the control ligands fit into the receptors. These interactions hint that such molecules influences HPO’s hormonal pathways and mineralization processes critical for reproductive health in poultry. Overall, the results support traditional claims about Aloes Granules, suggesting they have multiple targets within the body. To deepen our understanding, follow-up studies like molecular dynamics simulations or in-vitro testing are necessary. These steps will help clarify whether these interactions translate into meaningful biological effects.